Methanol → 5-[(4-Fluorophenoxy)methyl]tetrahydro-3-furanthiol

HRID 54773Notes

Reaction equation

HRID 54773 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][CH2:7][C@@H:8]2[O:12][CH2:11][C@@H:10]([S:13]C(=O)C)[CH2:9]2)=[CH:4][CH:3]=1.[Na].CO>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]2[O:12][CH2:11][CH:10]([SH:13])[CH2:9]2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 86750320Ethanethioic acid trans-(+/-)-S-[5-[(4-fluorophenoxy)methyl]tetrahydro-3-furanyl]ester

Product 1

HCID 189240045-[(4-Fluorophenoxy)methyl]tetrahydro-3-furanthiolYield 52.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared by the procedure of Example 16 using 0.943 g of product from Example 35, 0.86 ml of 25% .sodium methhoxide/methyl alcohol and 12 ml of tetrahydrofuran to give 0.417 g of the desired product.

Sources & evidence

ORD record
ord-3ce85b28e88b461fa73e7fec6b5c1517
Source dataset
uspto-grants-1997_04
Patent number
US05623081

Reaction notes

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