反应详情

A mixture of 8.9 g of L-phenylalanine, 4.8 ml of trichloromethylchloroformate (Diphosgene), 70 ml of dry tetrahydrofuran and 0.135 g of activated carbon is heated in an oil bath at 55° C. for 2 hours, until the L-phenylalanine is in solution. The reaction is filtered through diatomaceous earth. The filtrate is concentrated in vacuo, treated with diethyl ether and hexane, and the resulting crystals are collected to give 1.04 g of the desired product.

1. filtrationThe reaction is filtered through diatomaceous earth
2. concentrationThe filtrate is concentrated in vacuo
3. additiontreated with diethyl ether and hexane
4. customthe resulting crystals are collected