反应详情

温度

0 °C

To a solution of (2-methyl-4-{3-[3-(3-morpholin-4-yl-prop-1-ynyl)-5-(4-trifluoromethylphenylethynyl)-phenyl]-prop-2-ynyloxy}-phenoxy)-acetic acid methyl ester (0.26 g, 0.51 mmol) in THF (5.3 ml) and methanol (1 ml) was added a ice-cold solution of LiOH (1 M, 5.3 ml). The reaction mixture was stirred at 0° C. for 45 min., after which water (10 ml) and aqueous HCl (1M, 7.4 ml) were added. The mixture was extracted with ethyl acetate (2×80 ml), and the combined organic phases were dried and evaporated to give the title compound in 272 mg (94%) yield.

1. extractionThe mixture was extracted with ethyl acetate (2×80 ml)
2. customthe combined organic phases were dried
3. customevaporated