反应详情

To a well stirred solution of guaiacol (10.0 g, 80.55 mmol) and propargyl bromide (11.5 g, 96.66 mmol) in DMF (100 mL) was added anhydrous K2CO3 (22.0 g, 161.2 mmol) and the mixture was stirred at room temperature for 34 hours. The mixture was then filtered to remove inorganic material. Filtrate was concentrated under vacuo and diluted with water (250 mL). It was then extracted with ethyl acetate (3×100 mL). The combined organic layers were washed with water (2×100 mL) and dried over anhydrous sodium sulfate. Removal of solvent under vacuo gave the product (13.0 g) as brown oil.

1. filtrationThe mixture was then filtered
2. customto remove inorganic material
3. concentrationFiltrate was concentrated under vacuo
4. additiondiluted with water (250 mL)
5. extractionIt was then extracted with ethyl acetate (3×100 mL)
6. washThe combined organic layers were washed with water (2×100 mL)
7. dry with materialdried over anhydrous sodium sulfate
8. customRemoval of solvent under vacuo