Hydrochloric Acid → HCID 67158972, compound

HRID 549393Notes

Reaction equation

HRID 549393 reaction equation
Cl.C1(C)C=CC(S(O)(=O)=O)=CC=1.C[O:14][CH:15]=[CH:16][C:17]1[C:18]([C:26]([OH:29])([CH3:28])[CH3:27])=[N:19][N:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=12>>[CH3:27][C:26]1([CH3:28])[C:18]2[C:17](=[C:21]3[N:20]([N:19]=2)[CH:25]=[CH:24][CH:23]=[CH:22]3)[CH2:16][CH:15]([OH:14])[O:29]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6101p-Toluenesulfonic acidHCID 67158634HCID 67158634, compound

Product 1

HCID 67158972HCID 67158972, compoundYield 60.2%

Procedure

Following procedures analogous to those described in Example 6 Step b, using concentrated hydrochloric acid (0.5 mL, 6 mmol) in lieu of p-toluenesulfonic acid, 2-[3-(2-methoxy-vinyl)-pyrazolo[1,5-a]pyridin-2-yl]-propan-2-ol (1.23 g, 5.30 mmol) was converted to 1,1-dimethyl-3,4-dihydro-1H-2-oxa-8a,9-diaza-fluoren-3-ol (0.697 g, 3.19 mmol, 60% yield) as a light yellow solid.

Sources & evidence

ORD record
ord-b9b75a0456ae44b5a477d899ea57c1f5
Source dataset
uspto-grants-2011_05
Patent number
US07943652B2

Reaction notes

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