Hydrochloric Acid → HCID 136355283, compound

HRID 550782Notes

Reaction equation

HRID 550782 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]2[NH:10][C:11](=[O:25])[C:12]3[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:13]=3[N:14]=2)=[C:4]([F:26])[CH:3]=1.C(Cl)(Cl)Cl.CO.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]2[NH:10][C:11](=[O:25])[C:12]3[CH2:17][NH:16][CH2:15][C:13]=3[N:14]=2)=[C:4]([F:26])[CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6212ChloroformHCID 136188089HCID 136188089, compound

Product 1

HCID 136355283HCID 136355283, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of tert-butyl 2-(4-chloro-2,5-difluorophenyl)-4-oxo-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d]pyrimidine-6-carboxylate, chloroform, and MeOH, 4M hydrogen chloride (HCl) in ethyl acetate (EtOAc) solution was added, and the resultant mixture was stirred at ambient temperature for 5 hours to yield 2-(4-chloro-2,5-difluorophenyl)-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one hydrochloride.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-17c6781c853448268f282db5f587d041
Source dataset
uspto-grants-2011_05
Patent number
US07947690B2

Reaction notes

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