Diisopropylethylamine → HCID 178427144, compound

HRID 551239Notes

Reaction equation

HRID 551239 reaction equation
C[C:2]1([CH3:18])[CH2:6][N:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=2[CH3:16])[C:4](=[O:17])N1.[Cl:19][C:20]1[CH:31]=[CH:30][C:23]2[NH:24][C:25]([C@@H:27]([NH2:29])[CH3:28])=[N:26][C:22]=2[CH:21]=1.CN([C:35]([O:39]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>C1COCC1>[Cl:19][C:20]1[CH:31]=[CH:30][C:23]2[NH:24][C:25]([C@@H:27]([NH:29][C:11](=[O:13])[C:10]3[CH:14]=[CH:15][C:7]([N:5]4[CH2:6][CH2:2][CH2:18][CH2:35][O:39][C:4]4=[O:17])=[C:8]([CH3:16])[CH:9]=3)[CH3:28])=[N:26][C:22]=2[CH:21]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 42034613(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 667315354-(4,4-Dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoic acid

Product 1

HCID 178427144HCID 178427144, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 1f from 4-(4,4-dimethyl-2-oxo-imidazolidin-1-yl)-3-methyl-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine, TBTU and DIPEA in THF and purification of the residue by chromatography on silica gel.

Sources & evidence

ORD record
ord-a87f2053c8a04e978b138e90372dcc3b
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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