反应详情

152.6 g of potassium carbonate and 15.3 g of cesium carbonate are added to a solution of 122 g of 3-hydroxy-2-iodopyridine and 65.7 ml of benzyl bromide in 1.5 l of dimethylformamide, and the suspension is stirred under argon atmosphere for 20 hours at room temperature. The reaction mixture is filtered, the filter residue is washed with dichloromethane, the filtrate is concentrated by evaporation, and the residue is chromatographed on silica gel with hexane/10-20% ethyl acetate. 146.3 g of 3-benzyloxy-2-iodopyridine is obtained as oil.

1. filtrationThe reaction mixture is filtered
2. washthe filter residue is washed with dichloromethane
3. concentrationthe filtrate is concentrated by evaporation
4. customthe residue is chromatographed on silica gel with hexane/10-20% ethyl acetate