反应详情

[4-(2-Hydroxyethyl)benzyl]-(2-phenylethyl)carbamic acid tert-butyl ester (238 mg) in dichloromethane (10 mL) was treated with Dess-Martin periodinane (341 mg) and stirred for 1 hour. The reaction mixture was added to a mixture of ethyl acetate (10 mL), saturated aqueous sodium thiosulphate solution (10 mL) and saturated aqueous sodium bicarbonate (10 mL), and the mixture was stirred vigorously for 10 minutes. The phases were separated. The aqueous layer was extracted with ethyl acetate and the combined organics were washed with water, dried (magnesium sulfate) and evaporated to give the subtitle compound as an oil (232 mg).

1. stirringthe mixture was stirred vigorously for 10 minutes
2. customThe phases were separated
3. extractionThe aqueous layer was extracted with ethyl acetate
4. washthe combined organics were washed with water
5. dry with materialdried (magnesium sulfate)
6. customevaporated