反应详情

3-Aminopropanol (3.94 g, 52.5 mmol) and triethylamine (1.77 g, 17.5 mmol) were dissolved in tetrahydrofuran (30 ml) and added with 2-nitrobenzyl chloride (3.00 g, 17.5 mmol) at room temperature. After heated to reflux for seven hours, the reaction mixture was allowed to cool and poured into 1N hydrochloric acid water and extracted with ether. The aqueous layer was adjusted to pH 9 with a saturated sodium hydrogen carbonate aqueous solution and then extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 3-(2-nitrobenzylamino)propanol (1.22 g).

1. temperatureAfter heated
2. temperatureto reflux for seven hours
3. temperatureto cool
4. extractionextracted with ether
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with a saturated brine
7. dry with materialdried over anhydrous sodium sulfate
8. customthe solvent was evaporated under reduced pressure