huagongshe.com
HRID553841

反应详情

EQUATION

反应方程式

HRID 553841 的结构方程式

REACTANTS

反应物

4
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CC(C)(C)[Si](C)(C)Cl
HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：COC(=O)C(C)(C)CO
HCID84152

Methyl 3-hydroxypivalate

C6H12O3

结构：O=S(=O)([O-])O.[Na+]
HCID516919

Sodium hydrogen sulfate

HNaO4S

PRODUCTS

生成物

1
结构：COC(=O)C(C)(C)CO[Si](C)(C)C(C)(C)C
HCID12044793

未命名化合物

收率 32.5%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Methyl 2,2-dimethyl-3-hydroxypropionate (1.32 g), tert-butyldimethylsilyl chloride (1.8 g), 4-dimethylaminopyridine (122 mg) and NEt3 (1.67 ml) were dissolved in DCM (100 ml) and stirred for 16 h at RT. A NaHSO4 solution was added, and the org. phase was further washed with water, dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/4) afforded 800 mg of the desired compound.

WORKUP

后处理

  1. washphase was further washed with water
  2. dry with materialdried (Na2SO4)
  3. customevaporated off