Ethyl Acetoacetate → HCID 14689361, compound

HRID 554208Notes

Reaction equation

[O:1]=[C:2]([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[H-].[Na+].Br[CH:13]([CH3:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15]>>[C:2]([CH:3]([CH:13]([CH3:22])[C:14](=[O:15])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])(=[O:1])[CH3:9]

Participants

Reactant 3

HCID 8868Ethyl Acetoacetate

HCID 164522-Bromopropiophenone

HCID 24758Sodium hydride

Product 1

HCID 14689361HCID 14689361, compoundYield 90%

Procedure

Using ethyl 3-oxobutanoate (12.2 g), sodium hydride (60% in oil, 4.24 g) and 2-bromopropiophenone (22.0 g), a procedure as in Reference Example 13 was performed to give the title compound as a brown oil (yield 22.1 g, 90%).

Sources & evidence

ORD record: ord-350e36fc4d5c4658bfa39324d42ddace
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048909B2

Reaction notes

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