Methanamine, hydrochloride (1:1) → HCID 66925178, compound

HRID 554389Notes

Reaction equation

HRID 554389 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]=[C:10]([CH:23]=O)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[Cl-:25].[CH3:26][NH3+:27].C([BH3-])#N.[Na+]>>[ClH:25].[CH3:26][NH:27][CH2:23][C:10]1[CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=2)[N:12]([S:13]([C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)(=[O:14])=[O:15])[CH:11]=1

Participants

4

Reactant 3

HCID 11637Methanamine, hydrochloride (1:1)HCID 5003444Sodium cyanoborohydrideHCID 86620773HCID 86620773, compound

Product 1

HCID 66925178HCID 66925178, compoundYield 53.1%

Procedure

Using 5-(3-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde (0.36 g), methylammonium chloride (0.89 g) and sodium cyanoborohydride (0.21 g), a procedure as in Example 4 was performed to give the title compound as white crystals (yield 0.22 g, 52%).

Sources & evidence

ORD record
ord-6322145a48a34674ad38984a61343f73
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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