Methanamine, hydrochloride (1:1) → HCID 66925163, compound

HRID 554392Notes

Reaction equation

HRID 554392 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH:11]=[C:10]([CH:23]=O)[CH:9]=1.[Cl-:25].C[NH3+].[C:28]([BH3-])#[N:29].[Na+]>>[ClH:25].[CH3:28][NH:29][CH2:23][C:10]1[CH:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[N:12]([S:13]([C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)(=[O:14])=[O:15])[CH:11]=1

Participants

4

Reactant 3

HCID 11637Methanamine, hydrochloride (1:1)HCID 5003444Sodium cyanoborohydrideHCID 86620775HCID 86620775, compound

Product 1

HCID 66925163HCID 66925163, compoundYield 80%

Procedure

Using 5-(2-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde (0.46 g), methylammonium chloride (1.11 g) and sodium cyanoborohydride (0.26 g), a procedure as in Example 4 was performed to give the title compound as colorless crystals (yield 0.37 g, 80%).

Sources & evidence

ORD record
ord-6a569cc779b24669a980d8f48830f9cd
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

Loading…