Methanamine, hydrochloride (1:1) → HCID 66924883, compound

HRID 554393Notes

Reaction equation

HRID 554393 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]=[C:10]([CH:23]=O)[CH:9]=2)=[CH:4][CH:3]=1.[Cl-].C[NH3+].[C:28]([BH3-])#[N:29].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]=[C:10]([CH2:23][NH:29][CH3:28])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11637Methanamine, hydrochloride (1:1)HCID 5003444Sodium cyanoborohydrideHCID 86620776HCID 86620776, compound

Product 1

HCID 66924883HCID 66924883, compoundYield 72%

Procedure

Using 5-(4-fluorophenyl)-1-[(4-fluorophenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde (0.52 g), methylammonium chloride (1.20 g) and sodium cyanoborohydride (0.28 g), a procedure as in Example 6 was performed to give the title compound as a colorless oil (yield 0.39 g, 72%).

Sources & evidence

ORD record
ord-74892cc3348848e78a9baac66fb460d3
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

Loading…