Methanamine, hydrochloride (1:1) → HCID 66925140, compound

HRID 554397Notes

Reaction equation

HRID 554397 reaction equation
[CH3:1][C:2]1[N:3]([S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][C:6]=1[CH:7]=O.[Cl-:24].C[NH3+].[C:27]([BH3-])#[N:28].[Na+]>>[ClH:24].[CH3:27][NH:28][CH2:7][C:6]1[CH:5]=[C:4]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:3]([S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:2]=1[CH3:1]

Participants

4

Reactant 3

HCID 11637Methanamine, hydrochloride (1:1)HCID 5003444Sodium cyanoborohydrideHCID 86232862HCID 86232862, compound

Product 1

HCID 66925140HCID 66925140, compoundYield 35.2%

Procedure

Using 2-methyl-5-phenyl-1-phenylsulfonyl-1H-pyrrole-3-carbaldehyde (0.27 g), methylammonium chloride (0.68 g) and sodium cyanoborohydride (0.28 g), a procedure as in Example 4 was performed to give the title compound as colorless crystals (yield 0.11 g, 35%).

Sources & evidence

ORD record
ord-288a5b7f3b854531aa8d5b1856bde1f3
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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