Methanamine, hydrochloride (1:1) → HCID 66925152, compound

HRID 554410Notes

Reaction equation

HRID 554410 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:14][C:13]([CH:22]=O)=[C:12]2[CH3:24])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[Cl-].C[NH3+].[C:28]([BH3-])#[N:29].[Na+]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:14][C:13]([CH2:22][NH:29][CH3:28])=[C:12]2[CH3:24])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 11637Methanamine, hydrochloride (1:1)HCID 5003444Sodium cyanoborohydrideHCID 86620745HCID 86620745, compound

Product 1

HCID 66925152HCID 66925152, compoundYield 65.5%

Procedure

Using 1-[(3-chlorophenyl)sulfonyl]-2-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (171 mg), methylammonium chloride (311 mg) and sodium cyanoborohydride (103 mg), a procedure as in Example 4 was performed to give the title compound as a colorless oil (yield 64 mg, 34%).

Sources & evidence

ORD record
ord-e90679bd31a74292b62c8c7b1de46f0a
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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