反应详情

温度

110 °C

4-Chloro-8-nitroquinoline (176 mg, 0.85 mmol) and 4-aminophenol (93 mg, 0.85 mmol) were dissolved in dimethylformamide, and to which 1.0 M potassium tert-butoxide (0.95 mL) in tetrahydrofuran was slowly added dropwise at room temperature, which was then heated and stirred at 110° C. for seven hours. When the reaction was completed, the resultant was extracted with ethyl acetate and aqueous sodium chloride, and the combined organic layers were dried with anhydrous sodium sulfate, and then filtered. The solvent was removed by vacuum distillation, and the residue was purified by a column chromatography (ethyl acetate/n-hexane=½) to obtain 140.6 mg of the desired compound as a reddish brown solid (yield 59.0%).

1. temperaturewhich was then heated
2. extractionthe resultant was extracted with ethyl acetate and aqueous sodium chloride
3. dry with materialthe combined organic layers were dried with anhydrous sodium sulfate
4. filtrationfiltered
5. customThe solvent was removed by vacuum distillation
6. customthe residue was purified by a column chromatography (ethyl acetate/n-hexane=½)