Hydrochloric Acid → (R)-2-hydroxy-3-methoxycarbonyl-2-penten-4-olide

HRID 55453Notes

Reaction equation

C([Li])CCC.C(N[CH:10]([CH3:12])[CH3:11])(C)C.[CH3:13][O:14][C:15](=[O:20])C[C@H](O)C.CO[C:23](=[O:28])[C:24]([O:26]C)=[O:25].Cl>CCCCCC.O1CCCC1.C(OCC)(=O)C>[OH:28][C:23]1[C:24]([O:26][C@H:10]([CH3:11])[C:12]=1[C:15]([O:14][CH3:13])=[O:20])=[O:25]

Participants

Conditions

Temperature: 0 °C

Procedure

775 ml of 1.6M n-butyllithium solution in n-hexane are added dropwise within a period of 20 minutes at -25° C. to a solution of 1.27 mol of diisopropylamine in 600 ml of tetrahydrofuran. At -70° C., 70.9 g of (R)-3-hydroxybutyric acid methyl ester are then added dropwise within a period of 30 minutes and, after 1 hour, 70.9 g of oxalic acid dimethyl ester are added dropwise within a period of 40 minutes. After a reaction time of two hours at -60° C., the whole is warmed to 0° C. and acidified to pH 2 with 430 ml of 6N hydrochloric acid. The product is isolated by repeated extraction with ethyl acetate and pre-purified by extraction into aqueous bicarbonate solution, acidification with 6N hydrochloric acid to pH 2.5 and extraction once more with ethyl acetate. The solvent is distilled off and the residue is recrystallised from ether/petroleum ether. [α]D20 =+30.0° (3% in CHCl3), m.p. 94°-96° C.

Workup

custompre-purified by extraction into aqueous bicarbonate solution, acidification with 6N hydrochloric acid to pH 2.5 and extraction once more with ethyl acetate
distillationThe solvent is distilled off
customthe residue is recrystallised from ether/petroleum ether
custom[α]D20 =+30.0° (3% in CHCl3), m.p. 94°-96° C.

Sources & evidence

ORD record: ord-ecd6a5b30a544048af33089764496ebf
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05625059

Reaction notes

Loading…