反应详情

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester, dihydrochloride (0.108 g, 0.25 mmol), cyclopropanecarboxylic acid (0.02 mL, 0.30 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.073 g, 0.38 mmol), 1-hydroxybenzotriazole hydrate (0.051 g, 0.38 mmol), and triethylamine (0.16 mL, 1.14 mmol) were combined in CH2Cl2 (1 mL) and stirred at room temperature for 45 minutes. The mixture was diluted with aqueous NH4Cl and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by silica gel chromatography (0-100% EtOAc in hexanes) to give (5-{2-[(N-cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester.

1. extractionextracted with CH2Cl2
2. dry with materialThe combined organic layers were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated
5. customthe residue was purified by silica gel chromatography (0-100% EtOAc in hexanes)