反应详情

温度

50 °C

To (4,6-diethoxy-pyrimidin-2-yl)-acetic acid ethyl ester (0.218 g, 0.86 mmol) in THF (3 mL) was added 1N aqueous LiOH (2.58 mL, 2.58 mmol), and the reaction was stirred at 50° C. for 1 hour, and then at room temperature overnight. The mixture was acidified with 1N aqueous HCl and extracted three times with EtOAc. The combined organic layers were dried, filtered, and concentrated to give (4,6-diethoxy-pyrimidin-2-yl)-acetic acid.

1. customat room temperature
2. customovernight
3. extractionextracted three times with EtOAc
4. customThe combined organic layers were dried
5. filtrationfiltered
6. concentrationconcentrated