反应详情

温度

100 °C

415 mg (3.0 mMol) K2CO3 and 249 mg (1.5 mMol) KI are added to a solution of 192 mg (1.00 mMol) 6-hydroxy-benzofuran-3-carboxylic acid methyl ester (Step 9.4) and 258 mg (1.1 mMol) 4-benzyloxymethyl-6-chloro-pyrimidine (commercially available; [CAS: 914802-11-2]) in 1.6 ml NMP. This mixture is stirred for 4 h at 100° C., cooled to rt and diluted with water and EtOAc. The aq. phase is separated off and extracted twice with EtOAc. The organic layers are washed with a diluted solution of Na2S2O3 and brine, dried (Na2SO4) and concentrated. Chromatography (Combi Flash; hexane/EtOAc 19:1→1:1) and crystallization from hexane gives the title compound: m.p.: 85-86° C.; MS: [M+1]+=391; TLC(hexane/EtOAc 2:1): Rf=0.38.

1. temperaturecooled to rt
2. customThe aq. phase is separated off
3. extractionextracted twice with EtOAc
4. washThe organic layers are washed with a diluted solution of Na2S2O3 and brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customChromatography (Combi Flash; hexane/EtOAc 19:1→1:1) and crystallization from hexane