反应详情

Potassium carbonate (4.15 g) and methyl iodide (2.80 ml) were added to a solution of 6-methyl-2-nitro-3-hydroxypyridine (4.63 g) in DMF (120 ml), and the mixture was stirred at room temperature for 14 hours. The reaction mixture was distributed between ethylacetate and water. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from ethyl acetate/hexane to give the title compound (3.94 g) as needle crystals.

1. washThe organic layer was washed with saturated brine
2. dry with materialdried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue was recrystallized from ethyl acetate/hexane