反应详情

To a mixture of 1-(5-bromobenzo[b]thiophen-3-yl)-2-phenylethanone (1.1 g) and triethylsilane (1.5 g) was added trifluoro acetic acid (10 mL) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into an ice-cooled saturated potassium carbonate aqueous solution, and the mixture was extracted with diethyl ether. The organic layer washed with water and brine and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane) to give the title compound (0.94 g).

1. extractionthe mixture was extracted with diethyl ether
2. washThe organic layer washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was removed under reduced pressure
5. customThe residue was purified by column chromatography on silica gel (eluent: n-hexane)