反应详情

After suspending 4-amino-3-chlorophenol (23.7 g) in N,N-dimethylformamide (100 mL) and adding pyridine (23.4 mL) while cooling on ice, phenyl chloroformate (23.2 ml) was added dropwise below 20° C. Stirring was performed at room temperature for 30 minutes, and then water (400 mL), ethyl acetate (300 mL) and 6N HCl (48 mL) were added, the mixture was stirred and the organic layer was separated. The organic layer was washed twice with 10% brine (200 mL), and dried over magnesium sulfate. The solvent was removed to give 46 g of the title compound as a solid.

1. additionwas added dropwise below 20° C
2. stirringthe mixture was stirred
3. customthe organic layer was separated
4. washThe organic layer was washed twice with 10% brine (200 mL)
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed