反应详情

温度

60 °C

To a solution of 2-(5-(3-trifluoromethylphenylamino)-1,3,4-oxadiazol-2-yl) phenol (100 mg, 0.31 mmol; Reference Compound 9-(1)) and 4-chloromethylquinoline (55 mg, 0.31 mmol) in N,N-dimethylformamide (1.0 mL) was added potassium carbonate (86 mg, 0.62 mmol) at room temperature and then the mixture was stirred at 60° C. over night. The reaction solution was cooled to a room temperature and diluted with ethyl acetate (100 mL). The ethyl acetate solution was washed with a saturated brine solution (30 mL), dried over anhydrous sodium sulfate and concentrated under a reduced pressure. The residue was purified with a silica gel column chromatography (hexane/ethyl acetate) to give 39 mg (27%) of the titled compound as a colorless solid.

1. temperatureThe reaction solution was cooled to a room temperature
2. washThe ethyl acetate solution was washed with a saturated brine solution (30 mL)
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under a reduced pressure
5. customThe residue was purified with a silica gel column chromatography (hexane/ethyl acetate)