Acetyl chloride → HCID 25071455, compound

HRID 558451Notes

Reaction equation

HRID 558451 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].Cl.Cl.[NH2:7][C:8]1[N:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:33])[N:12]2[CH2:22][CH2:23][CH2:24][NH:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C(N(CC)CC)C>CN1C(=O)CCC1>[NH2:7][C:8]1[N:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:33])[N:12]2[CH2:22][CH2:23][CH2:24][N:25]([CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:1](=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 1317292856-Amino-9-[3-(benzylamino)propyl]-2-butoxy-7,9-dihydro-8H-purin-8-one, dihydrochloride

Product 1

HCID 25071455HCID 25071455, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Acetylchloride (0.08 ml) was added to a mixture of the product from step (viii) (250 mg) and triethylamine (0.6 ml) in NMP (5 ml) and stirred for 2 h. The mixture was purified by to RPHPLC, yield 85 mg.

Workup

  1. customThe mixture was purified by to RPHPLC, yield 85 mg

Sources & evidence

ORD record
ord-4b138ee9389641709c5cde81d89bef7b
Source dataset
uspto-grants-2011_11
Patent number
US08063051B2

Reaction notes

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