Hydrochloric Acid → Methyl 3,4-dihydro-2H-1,4-benzoxazine-5-carboxylate

HRID 560277Notes

Reaction equation

HRID 560277 reaction equation
B(F)(F)F.CCOCC.[CH3:10][O:11][C:12]([C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[O:23][CH2:22][C:21](=O)[NH:20][C:19]=12)=[O:13].[BH4-].[Na+].Cl.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1.CCOC(C)=O>[CH3:10][O:11][C:12]([C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[O:23][CH2:22][CH2:21][NH:20][C:19]=12)=[O:13]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 8000Boron trifluoride etherateHCID 10340Sodium CarbonateHCID 4311764Sodium borohydrideHCID 59153381HCID 59153381, compound

Product 1

HCID 14373654Methyl 3,4-dihydro-2H-1,4-benzoxazine-5-carboxylate

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
5 °C

Procedure

Boron trifluoride diethyl etherate (7.10 mmol) is added dropwise to a mixture of 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylic acid methyl ester (3.38 mmol) in THF (10 mL) to keep the temperature below 5° C. After 20 min sodium borohydride (7.10 mmol) is added and the mixture is stirred at 5° C. for 90 min. EtOAc (6.0 mL) and aq. HCl (1.0 M, 6.0 mL) are added dropwise. The mixture is made basic by addition of aq. Na2CO3 solution, the layers are separated and the aq. layer is extracted with EtOAc. The combined organic layers are dried over MgSO4 and concentrated in vacuo to give a crude product which is purified by FC (heptane to heptane/EtOAc 3/7). LC-MS: tR=0.90 min; [M+CH3CN+H]+=235.3.

Workup

  1. customthe temperature below 5° C
  2. customthe layers are separated
  3. extractionthe aq. layer is extracted with EtOAc
  4. dry with materialThe combined organic layers are dried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-dc3db26fba2c40cf8858d201287ed491
Source dataset
uspto-grants-2011_11
Patent number
US08063099B2

Reaction notes

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