反应详情

To a solution of 1-methylpiperazine (6.91 g, 69 mmol) and Et3N (6.98 g, 69 mmol) in EtOAc (60 mL) was added 1,2-difluoro-4-nitrobenzene (10.02 g, 63 mmol) dropwise with stirring and the mixture was stirred at rt overnight. The reaction mixture was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (14.75 g, 98%).

1. stirringthe mixture was stirred at rt overnight
2. washThe reaction mixture was washed with brine
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated in vacuo