Hydrochloric Acid → HCID 67000215, compound

HRID 561040Notes

Reaction equation

HRID 561040 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][C:9]=2[S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[CH:4][CH:3]=1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][C:9]=2[S:18]([C:21]2[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=2)(=[O:19])=[O:20])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25168520HCID 25168520, compound

Product 1

HCID 67000215HCID 67000215, compoundYield 159.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4-(4-chloro-phenyl)-3-(4-methyl-benzenesulfonyl)-quinoline (40 mg, 0.102 mmol) was dissolved in ethyl acetate (1.5 ml) and a solution of hydrogen chloride in ethyl acetate (c=1.6M, 0.14 ml, 0.224 mmol) was added dropwise to the solution. The solid was filtered off, washed with ethyl acetate and dried in vacuo to give 35 mg of the title compound in 80% yield.

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with ethyl acetate
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5ded5055852f4b5a8f77181019067400
Source dataset
uspto-grants-2011_11
Patent number
US08063220B2

Reaction notes

Loading…