反应详情

36.7 g (149 mmol) of 70% pure meta-chloroperbenzoic acid were added to 12.0 g (67.7 mmol) of the compound from Example 8A in 800 ml of tetrahydrofuran at 0° C., and the mixture was stirred at RT for 15 min. Addition of 100 ml of a saturated aqueous sodium sulfite solution was followed by extraction with ethyl acetate several times. The combined organic phases were washed five times with saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate, filtered and concentrated. 11.0 g (75% of theory) of the title compound were obtained.

1. extractionwas followed by extraction with ethyl acetate several times
2. washThe combined organic phases were washed five times with saturated aqueous sodium bicarbonate solution
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated