反应详情

2.00 g (11.33 mmol) of 4-chloro-2,6-difluorobenzaldehyde were dissolved in 15 ml of diethyl ether at 0° C., and 34.0 ml (16.99 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran were slowly added dropwise. After stirring at RT for 2 h, the reaction solution was mixed with 1N hydrochloric acid and ethyl acetate, and the phases were separated. The aqueous phase was extracted three times with diethyl ether. The combined organic phases were washed with saturated aqueous sodium chloride solution, and the solvents were removed in vacuo. The crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 1.20 g (48% of theory) of the title compound were obtained.

1. customthe phases were separated
2. extractionThe aqueous phase was extracted three times with diethyl ether
3. washThe combined organic phases were washed with saturated aqueous sodium chloride solution
4. customthe solvents were removed in vacuo
5. customThe crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)