Potassium Carbonate → HCID 22467254, compound

HRID 561793Notes

Reaction equation

HRID 561793 reaction equation
C([C:3]1[C:8]([CH3:9])=[C:7]([Cl:10])[CH:6]=[CH:5][C:4]=1[OH:11])C.C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH2:20][O:21][CH3:22]>CC(C)=O>[Cl:10][C:7]1[CH:6]=[CH:5][C:4]([O:11][CH2:19][CH2:20][O:21][CH3:22])=[CH:3][C:8]=1[CH3:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 22134509Ethyl 4-chloro-3-methylphenol

Product 1

HCID 22467254HCID 22467254, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of ethyl 4-chloro-3-methylphenol (1 eq.) in acetone (0.2 M) was added potassium carbonate (5 eq.) and 1-bromo-2-methoxyethane (1.3 eq.). The resulting suspension was refluxed for 25 h. The insolubles were removed via filtration and the filtrate was concentrated in vacuo to furnish the title compound.

Workup

  1. temperatureThe resulting suspension was refluxed for 25 h
  2. customThe insolubles were removed via filtration
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-224af951c7104183870510e77339fa69
Source dataset
uspto-grants-2011_11
Patent number
US08063105B2

Reaction notes

Loading…