反应详情

To a solution of 0.1 g of 6-aminobenzothiazole and 0.1 g of pyridine added to 5 ml of tetrahydrofuran and stirred at room temperature was introduced dropwise 0.2 g of 3-(benzoylamino)benzoyl chloride dissolved in 1 ml of tetrahydrofuran. The resulting solution was stirred at room temperature for 1 hour, and then ethyl acetate and 1N hydrochloric acid were added thereto for separating the organic phase. The organic phase was washed with saturated sodium hydrogen carbonate solution one time, and then dried over anhydrous magnesium sulfate. The solution was filtered off, the filtrate was collected, and the solvent was removed under a reduced pressure to obtain a residue. The resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) to obtain 0.15 g of the desired product (Yield: 52%) as a white solid.

1. stirringThe resulting solution was stirred at room temperature for 1 hour
2. customfor separating the organic phase
3. washThe organic phase was washed with saturated sodium hydrogen carbonate solution one time
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationThe solution was filtered off
6. customthe filtrate was collected
7. customthe solvent was removed under a reduced pressure
8. customto obtain a residue
9. customThe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)