反应详情

Under argon and with ice cooling, a solution of 5.4 g (purity 50%, 26.7 mmol) of ethyl oxoacetate in 50 ml of THF was quickly added dropwise to 7.6 g (48 mmol, 1.8 eq.) of bromo(cyclopropylmethyl)magnesium. The reaction mixture was stirred for another 48 h, diluted with ethyl acetate and quenched with water. Celite was added, and the reaction mixture was stirred for 5 min and then filtered. After phase separation, the organic phase was washed once with water, dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 2.6 g (60% of theory)

1. customquenched with water
2. additionCelite was added
3. stirringthe reaction mixture was stirred for 5 min
4. filtrationfiltered
5. customAfter phase separation
6. washthe organic phase was washed once with water
7. dry with materialdried (sodium sulphate)
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure