Lithium Hydroxide → HCID 21266528, compound

HRID 566727Notes

Reaction equation

HRID 566727 reaction equation
C([O:4][CH:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12]2[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=2)[CH:6]1[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)(=O)C.[Li+].[OH-]>C1COCC1.O>[OH:4][CH:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12]2[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=2)[CH:6]1[C:19]1[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 21266451HCID 21266451, compound

Product 1

HCID 21266528HCID 21266528, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-acetoxy-4-m-tolyl-5,6-dihydro-1H-[5,4′]bipyridinyl-2-one (200 mg, 0.6 mmole) in THF (2 mL) and water (2 mL) at r.t. was added LiOH (51 mg, 1.2 mmole) in one portion. The reaction mixture was stirred at that temperature for 10 min before quenching the mixture with aqueous NH4Cl. The reaction was quenched with 1.45 mL of 1N HCl the resulting white precipitate was filtered, rinsed with water and dried to give the title compound as a white solid.

Workup

  1. custombefore quenching the mixture with aqueous NH4Cl
  2. customThe reaction was quenched with 1.45 mL of 1N HCl the resulting white precipitate
  3. filtrationwas filtered
  4. washrinsed with water
  5. customdried

Sources & evidence

ORD record
ord-3ceb84deacad46f8b90e891aa15f82a6
Source dataset
uspto-grants-2001_01
Patent number
US06174901B1

Reaction notes

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