Hydrochloric Acid → HCID 70219239, compound

HRID 566843Notes

Reaction equation

HRID 566843 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][C:12]([CH3:37])([CH3:36])[CH2:13][O:14][C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[O:16])=[O:9])[CH2:4][CH2:3]1.[ClH:38]>C(OCC)(=O)C>[ClH:38].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][CH2:11][C:12]([CH3:36])([CH3:37])[CH2:13][O:14][C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[O:16])=[O:9])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70216235HCID 70216235, compound

Product 1

HCID 70219239HCID 70219239, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To an ethyl acetate solution (25 ml) containing 2.500 g of 2,2-dimethyl-3-{[(octadecylamino)carbonyl]oxy}propyl 4-methyltetrahydro-1(2H)-pyrazinecarboxylate was added 1.42 ml of a 4N hydrogen chloride solution in ethyl acetate, followed by stirring at room temperature for 0.5 hour. After the reaction mixture was concentrated under reduced pressure, the resulting residue was recrystallized from a mixture of ethanol and ethyl acetate to obtain 2.323 g of the title compound in the form of a white solid.

Workup

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. customthe resulting residue was recrystallized from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-10f9b2f114ed448eb8b6264adbe39e88
Source dataset
uspto-grants-2001_01
Patent number
US06177067B1

Reaction notes

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