反应详情

25.2 g (131.2 mmol) of 6-hydroxy-2,2-dimethylchroman-4-one were introduced into 350 ml of diethyl ketone with stirring at RT and, after addition of 18.0 g (131 mmol) of powdered potassium carbonate, stirred at 75° C. for 30 min. After cooling to 60° C., 15.7 ml (131 mmol) of benzyl bromide were added dropwise, the mixture was concentrated in vac. after 2 h, the residue was treated with water and the solid was filtered off with suction, 37 g, m.p. 105-107° C.

1. stirringstirred at 75° C. for 30 min
2. temperatureAfter cooling to 60° C.
3. concentrationthe mixture was concentrated in vac
4. additionthe residue was treated with water
5. filtrationthe solid was filtered off with suction, 37 g, m.p. 105-107° C.