4-Nitrobenzaldehyde → HCID 21264431, compound

HRID 567108Notes

Reaction equation

HRID 567108 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH2:8].[N+:9]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1)([O-:11])=[O:10].C(N(CC)CC)C>C(O)C>[N+:9]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[N:8][CH2:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=1)([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 5414-NitrobenzaldehydeHCID 8471TriethylamineHCID 116521Thiopheneethanamine

Product 1

HCID 21264431HCID 21264431, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2-Thienyl)-ethylamine (5 g, 39.4 mmol), 4-nitrobenzaldehyde and triethylamine (10 ml) were dissolved in ethanol (100 ml). The reaction mixture was stirred at room temperature for 48 hours. The solid formed was filtered and dried to afford 7.75 g (76%) (4-nitrobenzylidene)-(2-thiophen-2-yl-ethyl)-amine.

Workup

  1. customThe solid formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-fcc09dbcfab045de933e252b3ca7ee13
Source dataset
uspto-grants-2001_01
Patent number
US06177443B1

Reaction notes

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