Benzyl chloroformate → HCID 23713430, compound

HRID 567195Notes

Reaction equation

HRID 567195 reaction equation
[H-].[Na+:2].[OH-].[OH-].[OH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([O-:15])(=[O:14])=[O:13])=[CH:8][CH:7]=1.[Na+].Cl[C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>O1CCCC1>[CH2:21]([O:20][C:18]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([O-:15])(=[O:13])=[O:14])=[CH:8][CH:7]=1)=[O:19])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Na+:2]

Participants

5

Reactant 3

HCID 10387Benzyl chloroformateHCID 24758Sodium hydrideHCID 22456370HCID 22456370, compound

Product 1

HCID 23713430HCID 23713430, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To an aqueous solution (40 ml) of sodium hydride (3.8 g), sodium 4-hydroxybenzenesulfonate dihydroxide (20 g) and tetrahydrofuran (28 ml) was added. To the mixture, benzyl chloroformate (12.3 ml) was added at 0° C. The mixture was stirred for 1 hour at 0° C. and for 1 hour at room temperature. The reaction mixture was concentrated. The precipitated crystals was washed with water and dried to give the title compound (18.1 g) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washThe precipitated crystals was washed with water
  3. customdried

Sources & evidence

ORD record
ord-3f4b0993987043b3ab5047b0809abe8b
Source dataset
uspto-grants-2001_01
Patent number
US06177466B1

Reaction notes

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