反应详情

A suspension of para-toluenethiosulphonic acid potassium salt (8.77 g), trimethyl 4-bromoorthobutyrate (8.00 g) and 18-crown-6 (10.24 g) in anhydrous tetrahydrofuran (60 ml) was ultrasonicated for 5 minutes then stirred at room temperature for 3 days. The mixture was poured into saturated aqueous sodium bicarbonate solution (200 ml) and extracted with ether (2×200 ml). The organic extracts were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give the subtitle compound (10.52 g) as an oil.

1. customwas ultrasonicated for 5 minutes
2. extractionextracted with ether (2×200 ml)
3. dry with materialThe organic extracts were dried over anhydrous sodium sulfate
4. filtrationfiltered
5. customevaporated under reduced pressure