Dimethylformamide → HCID 70219254, compound

HRID 568212Notes

Reaction equation

HRID 568212 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.C[N:12](C=O)C.N[C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=1[CH3:24]>C(N(CC)CC)C>[OH:23][C:20]1[CH:21]=[CH:22][C:17]([C:9]2[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[C:6]([NH2:12])=[O:7])=[C:18]([CH3:24])[CH:19]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 134054-Methylbenzoyl ChlorideHCID 178194-Amino-m-cresol

Product 1

HCID 70219254HCID 70219254, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

4-Methylbenzoyl chloride was added to a DMF solution of a mixture of 4-amino-3-methylphenol and triethylamine, and stirred at room temperature for 30 minutes. The relative amount of each compound used, and the purification of the product. is described in Production Example 4. Thus was obtained the intended product, 4-hydroxy-2-methylphenyl-4-methylbenzamide (yield: 12%).

Workup

  1. customthe purification of the product

Sources & evidence

ORD record
ord-6313b33ec239490388b1ad5064ffb9a9
Source dataset
uspto-grants-2001_01
Patent number
US06180844B2

Reaction notes

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