Dabco → HCID 14099146, compound

HRID 568305Notes

Reaction equation

HRID 568305 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][CH:3]=1.N12CCN(CC1)CC2.[CH3:17][CH:18]([N:20]=[C:21]=[O:22])[CH3:19]>CN(C)C=O>[Cl:8][C:6]1[N:5]=[N:4][CH:3]=[C:2]([NH:1][C:21]([NH:20][CH:18]([CH3:19])[CH3:17])=[O:22])[CH:7]=1

Participants

5

Reactant 3

HCID 9237DabcoHCID 61277Isopropyl isocyanateHCID 140991446-Chloropyridazin-4-amine

Product 1

HCID 14099146HCID 14099146, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of 0.8 gram of 4-amino-6-chloro-pyridazine in 30 ml of dimethylformamide is added 0.2 gram of 1,4-diazabicyclo[2.2.2]octane, followed by 0.6 gram of 1-methylethyl isocyanate. The reaction mixture is stirred at ambient temperature for 18 hours, then at 60° C. for six hours. The majority of the dimethylformamide is removed under reduced pressure, and the residue is slurried in water. The resultant solid is collected by filtration and dried to yield N-(6-chloro-4-pyridazinyl)-N'-(1-methylethyl)urea.

Workup

  1. waitat 60° C. for six hours
  2. customThe majority of the dimethylformamide is removed under reduced pressure
  3. filtrationThe resultant solid is collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-8c2dd2deef404a8cae116669538e97fa
Source dataset
uspto-grants-1988_03
Patent number
US04728355

Reaction notes

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