Hydrochloric Acid → HCID 13784605, compound

HRID 569092Notes

Reaction equation

HRID 569092 reaction equation
[CH:1]([C:3]1[C:4]([OH:16])=[C:5]([O:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:6]=[CH:7][CH:8]=1)=O.[C:17](#[N:21])[CH2:18][C:19]#N.[F-].[K+].Cl.C([OH:27])C>>[C:17]([C:18]1[C:19](=[O:27])[O:16][C:4]2[C:3]([CH:1]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[O:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])#[N:21]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8010MalononitrileHCID 522689Potassium FluorideHCID 20148679HCID 20148679, compound

Product 1

HCID 13784605HCID 13784605, compound

Procedure

In 25 ml of ethanol was dissolved 4.3 g of 4-(3-formyl-2-hydroxyphenyloxy)butyric acid and 1.35 g of malononitrile, to which 3 ml of an aqueous solution containing 0.12 g of potassium fluoride was added at 40° C. and the mixture was vigorously stirred for 2 minutes. Then 5 ml of concentrated hydrochloric acid was added and the mixture was stirred for 3 minutes, followed by ice-cooling. A precipitate was filtered and recrystallized to give a desired compound.

Workup

  1. additionwas added at 40° C.
  2. stirringthe mixture was stirred for 3 minutes
  3. temperaturecooling
  4. filtrationA precipitate was filtered
  5. customrecrystallized

Sources & evidence

ORD record
ord-b218690de1f64504ba276e81d7849420
Source dataset
uspto-grants-1988_03
Patent number
US04731375

Reaction notes

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