Hydrochloric Acid → HCID 20142835, compound

HRID 569837Notes

Reaction equation

HRID 569837 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH2:31])[CH3:27].Cl>C1COCC1>[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH:31][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:27]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 12176Glycine ethyl esterHCID 16757Benzenepentanoic acidHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 20142835HCID 20142835, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Phenylvaleric acid (2.67 g, 15 mmol) in distilled THF was reacted with CDI (15 mmol) followed by glycine ethyl ester.HCl (15 mmol) and C2H5)3N (15 mmol) as described in Example 56 Part A. The crude material (3.25 g, 82%) was used without purification.

Workup

  1. customThe crude material (3.25 g, 82%) was used without purification

Sources & evidence

ORD record
ord-673502bc98bd40afa693f171405de2d8
Source dataset
uspto-grants-1988_03
Patent number
US04734425

Reaction notes

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