Triethylamine → HCID 20142835, compound

HRID 569941Notes

Reaction equation

HRID 569941 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH2:31])[CH3:27].Cl.N(CC)(CC)CC>C1COCC1>[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH:31][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:27]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 16757Benzenepentanoic acidHCID 682631,1'-CarbonyldiimidazoleHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 20142835HCID 20142835, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Phenylvaleric acid (2.67 g, 15 mmol) in distilled THF was reacted with CDI (15 mmol) followed by glycine ethyl ester·HCl (15 mmol) and (C2H5)3N (15 mmol) as described in Example 56 Part A. The crude material (3.25 g, 82%) was used without purification.

Workup

  1. customThe crude material (3.25 g, 82%) was used without purification

Sources & evidence

ORD record
ord-83ed4e70f21447f2b82de1c2d4746044
Source dataset
uspto-grants-1988_03
Patent number
US04734424

Reaction notes

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