反应详情

A mixture of methyl 2-amino-6-(hydroxymethyl)pyridine-3-carboxylate (296 mg), tert-butyl(chloro)dimethylsilane (298 mg), imidazole (218 mg) and N,N-dimethylformamide (8 ml) was stirred at room temperature for 15 min. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a white solid. The white solid was added to a mixture of 1-isothiocyanato-4-(2,2,2-trifluoroethoxy)benzene (670 mg), sodium hydride (60% in oil, 132 mg) and N,N-dimethylformamide (15 ml) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was acidified with 1M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (547 mg) as a white solid.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customto give a white solid
6. temperaturecooling
7. stirringthe mixture was stirred for 30 min
8. extractionextracted with ethyl acetate
9. washThe extract was washed with water and saturated brine
10. dry with materialdried over anhydrous magnesium sulfate
11. concentrationconcentrated under reduced pressure
12. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane)