Hydrogen iodide → HCID 178481972, compound

HRID 570946Notes

Reaction equation

HRID 570946 reaction equation
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:23])[NH:14][CH2:15][C:16](=O)[C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:6]2[N:5]=[N:4]1.I>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)[N:23]=3)=[C:6]2[N:5]=[N:4]1

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 1784819793-Methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide

Product 1

HCID 178481972HCID 178481972, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Conditions

Temperature
80 °C

Procedure

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (40 mg) in 3N HCl (3 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give the a mixture of the hydrochloride and hydroiodide salts of the title compound (24 mg).

Workup

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

Sources & evidence

ORD record
ord-d4c1abc50713406798b58db77ffdaf53
Source dataset
uspto-grants-2015_05
Patent number
US09024018B2

Reaction notes

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