Potassium Carbonate → HCID 61354803, compound

HRID 571238Notes

Reaction equation

HRID 571238 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]2=[O:13].C([O-])([O-])=O.[K+].[K+].Br[CH2:21][C:22]([O:24][CH3:25])=[O:23]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:7](=[O:12])[C:6]2=[O:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 383335-MethoxyisatinHCID 60984Methyl bromoacetate

Product 1

HCID 61354803HCID 61354803, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 5-methoxyindoline-2,3-dione (1 g, 5.64 mmol) in DMF (15 ml), K2CO3 (0.936 g, 6.77 mmol) and methyl 2-bromoacetate (0.628 ml, 6.77 mmol) were added, and the mixture was reacted under microwave irradiation for 1 hour at 100° C. Then the insoluble inorganic salts were filtered off, and the resulting crude title compound was obtained (1.6 g) and used in the next step without further purification. MS/ESI+ 250.1 [MH]+.

Workup

  1. customthe mixture was reacted under microwave irradiation for 1 hour at 100° C
  2. filtrationThen the insoluble inorganic salts were filtered off

Sources & evidence

ORD record
ord-771c62bb21494545b134a6fb5ba31129
Source dataset
uspto-grants-2015_05
Patent number
US09024027B2

Reaction notes

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