反应详情

温度

80 °C

Isoamyl nitrite (2.62 gm, 22.38 mmol) was added to the stirred solution of 4-cyclopropylpyridin-3-amine (1.0 g, 7.46 mmol) in dry THF (15 mL) under argon atmosphere. This was followed by the addition of diiodomethane (3.0 mL, 22.38 mmol) and copper iodide (1.42 g, 7.46 mmol). The resulting mixture was refluxed at 80° C. for 1 hour. The reaction mixture was cooled, filtered and the filtrate was partitioned between ethyl acetate and water. The organic layer was concentrated to yield the crude product. Purification by column chromatography on silica gel (15% ethyl acetate in hexane) afforded 600 mg of the product (34% yield).

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered
3. customthe filtrate was partitioned between ethyl acetate and water
4. concentrationThe organic layer was concentrated
5. customto yield the crude product
6. customPurification by column chromatography on silica gel (15% ethyl acetate in hexane)